(Last 5 years)

E. Wei, Y. Ben Ali, J. Lyon, H. Wang, Randy Nelson, V.W. Dolinsky, J. R. Dyck, G. A. Mitchell, G. S. Korbutt and R. Lehner. Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance and increases energy expenditure. Cell Metab. (in press)

J. Clendening, A. Pandyra, Z. Li, P. Boutros, A. Martirosyan, R. Lehner, I. Jurisica, S. Trudel and L. Penn. Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood (in press)

D. N. Brindley, B. P. Kok, P.C. Kienesberger, R. Lehner and J. R. Dyck. Shedding light on the enigma of myocardial lipotoxicity: The involvement of known and putative regulators of fatty acid storage and mobilization. Am. J. Physiol. Endocrinol. Metab. (in press)

V. Lo, B. Erickson, M. Thomason-Hughes, K.W.S. Ko, V.W. Dolinsky, R. Nelson and R. Lehner (2010) Arylacetamide deacetylase attenuates fatty acid-induced triacylglycerol accumulation in rat hepatoma cells. J. Lipid Res. 51, 368-377

K.W.S. Ko, B. Erickson and R. Lehner (2009) Es-x/Ces1 prevents triacylglycerol accumulation in McArdle RH7777 cells. Biochim. Biophys. Acta - MCBL 1791,1133-1143

B. Manmontri, M. Sariahmetoglu, J. Donkor, M. Bou Khalil, M. Sundaram, Z. Yao, K. Reue, R. Lehner and D.N. Brindley (2008) Glucocorticoids and cAMP selectively increase hepatic lipin-1 expression and insulin acts antagonistically. J. Lipid Res. 49, 1056-1067

C. Minahk, K.W. Kim, R. Nelson, B. Trigatti, R. Lehner and D.E. Vance (2008) Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J. Biol. Chem. 283, 6449-6458

E. Wei, M. Alam, F. Sun, L.B. Agellon, D.E. Vance and R. Lehner (2007) ApoB and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice. J. Lipid Res. 48, 2597-2606

H. Wang, D. Gilham and R. Lehner (2007) Proteomic and lipid characterization of apolipoproteinB-free luminal lipid droplets from mouse liver microsomes: Implications for very-low density lipoprotein assembly. J. Biol. Chem. 282, 33218-33226

E. Wei, W. Gao and R. Lehner (2007) Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux. J. Biol. Chem. 282, 8027-8035

M. Alam, D. Gilham, D.E. Vance and R. Lehner (2006) Mutation of F₄₁₇ but not of L₄₁₈ or L₄₂₀ in the lipid binding domain decreases activity of triacylglycerol hydrolase. J. Lipid Res. 47, 375-383

D. Gilham and R. Lehner (2006) Provision of lipids for very low density lipoprotein assembly. In: Advances in Biochemistry in Health & Disease book series, “Biochemistry of Atherosclerosis”, pp.121-149 (ed. S. Kaur Cheema, Springer, New York)

D. Gilham, K.R. Perreault, C.F.B. Holmes, D.N. Brindley, D.E. Vance and R. Lehner (2005) Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase. Biochim. Biophys. Acta - MCBL 1736, 189-199

D. Gilham and R. Lehner (2005) Techniques to measure lipase and esterase activity in vitro. Methods 36, 139-147

E. Wei, R. Lehner and D.E. Vance (2005) CCAAT/enhancer binding-protein alpha activates transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes. Biochem. J. 388, 959-966

D. Gilham, M. Alam, W. Gao, D.E. Vance and R. Lehner (2005) Triacylglycerol hydrolase is localized to the ER by an unusual retention sequence where it associates with nascent VLDL without utilizing the component lipids as substrates. Mol. Biol. Cell 16, 984-996

D. Gilham and R. Lehner (2004) Physiological role of triacylglycerol hydrolase. Rev. Endocr. Metab. Disord. 5, 303-309

K. Tedrick, T.C. Trischuk, R. Lehner and G. Eitzen (2004) Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Mol. Biol. Cell 15, 4609-4621

K. G. Soni, R. Lehner, P. Metalnikov, P. O'Donnell, M. Semache, W. Gao, K. Ashman, A. V. Pshezhetsky and G. A Mitchell (2004) Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J. Biol. Chem. 279, 40683-40689

V.W. Dolinsky, D. Gilham, M. Alam, D.E. Vance and R. Lehner (2004) Triacylglycerol hydrolase: Role in intracellular lipid metabolism. Cell. Mol. Life Sci. 61, 1633-1651

D. Sahoo, T.C. Trischuk, V.A.B. Drover, S. Ho, T. Chan, G. Chimini, L.B. Agellon, R. Agnihotri, G.A. Francis and R. Lehner. (2004) ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from primary rat and mouse hepatocytes. J. Lipid Res. 45, 1122-1131

M. Rasouli, T.C. Trischuk and R. Lehner (2004) Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes. Biochim. Biophys. Acta (MCBL) 1682, 92-101

V.W. Dolinsky, D.N. Douglas, R. Lehner and D.E. Vance (2004) Regulation of enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid, dexamethasone. Biochem. J. 378, 967-974