(Last 5 years)

REFEREED PUBLICATIONS:

Waite, K.A. and Vance, D.E. (2004) Dimethylethanolamine Does not Prevent Liver Failure in Phosphatidylethanolamine N-Methyltransferase-Deficient Mice Fed a Choline-Deficient Diet. Biochim. Biophys. Acta 1636, 175-182.

Dolinsky, V.W., Douglas, D.N., Lehner, R. and Vance, D.E. (2004) Regulation of the Enzymes of Hepatic Microsomal Triacylgylcerol Lipolysis and Re-Esterification by the Glucocorticoid Dexamethasone. Biochem. J. 378. 967-974

Hayashi, H., Campenot, R.B., Vance, D.E. and Vance, J.E. (2004) Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures. J. Biol. Chem. 279, 14009-14015

Kulinsky, A., Vance, D.E. and Vance, J.E. (2004) A Choline-Deficient Diet in Mice Inhibits neither the CDP-choline Pathway for Phosphatidylcholine Biosynthesis in Hepatocytes nor Apolipoprotein B Secretion. J. Biol. Chem. 279, 23916-23924.

Banchio, C., Schang, L.M. and Vance, D.E. (2004) Phosphorylation of Sp1 by Cyclin-dependent Kinase 2 Modulates the Role of Sp1 in CTP:phosphocholine Cytidylyltransferase a Regulation during the S Phase of the Cell Cycle. J. Biol. Chem. 279, 40220-40226.

Jacobs, René L., Devlin, C., Tabas, I. and Vance, D.E. (2004) Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase a in mice decreases plasma high density and very low density lipoproteins. J. Biol. Chem. 279, 47402-47410.

Pan, H.-J., Reifsnyder, P., Vance, D.E., Xiao, Q and Leiter, E.H. (2005) Pharmacogenetic Analysis of Rosiglitazone-Induced Heaptosteatosis in New Mouse Models of Thpe 2 Diabetes. Diabetes 54, 1854-1862.

Wei, E., Lehner, R. and Vance, D.E. (2005) CEBPa Activates Transcription of Triacylglycerol Hydrolase in 3T3-L1 Adipocytes. Biochem. J. 387, 779-788.

Karten, B., Hayashi, H., Francis, G.A., Campenot, R.B., Vance, D.E., and Vance, J.E. (2005) Generation and Function of Astroglial Lipoproteins from Niemann-Pick Type C1-Deficient Mice. Biochem. J. 387, 779-788.

Shields, D.J., Lingrell, S., Agellon, L.B., Brosnan, J.T. and Vance, D.E. (2005) Localization-Independent Regulation of Homocysteine Secretion by Phosphatidylethanolamine N-Methyltransferase. J. Biol. Chem. 280, 27339-27344.

Jacobs, R.L., Stead, L.M., Devlin, C., Tabas, I., Brosnan, M.E., Brosnan, J.T. and Vance, D.E. (2005) Physiological Regulation of Phospholipid Methylation Alters Plasma Homocysteine in Mice. J. Biol. Chem. 280, 28299-28305.

Gilham, D., Alam, M., Gao, W., Vance, D.E., and Lehner, R. (2005) Triacylglcyerol Hydrolase Is Localized to the Endoplasmic Reticulum by an Unusual Retrieval Sequence where It Participates in VLDL Assembly without utilizing VLDL Lipids as Substrates. Mol. Biol. Cell 16, 984-996.

Gilham, D. Perreault, K.R., Holmes, C.F.B., Brindley, D.N. Vance, D.E. and Lehner, R. (2005) Insulin, Glucagon, and Fatty Acid Treatment of Hepatocytes Does not Result in Phosphorylation or Changes in Activity of Triacylglycerol Hydrolase. BBA Mol. Cell Biol. Lipids 1736, 189-199.

Li, Z., Agellon, L. and Vance, D.E. (2005) Phosphatidylcholine homeostasis and liver failure. J. Biol. Chem. 280, 37798-37802.

Sugimoto, H., Okamura, K., Sugimoto, S., Satou, M., Hattori, T., Vance, D.E. and Izumi, T. (2005) Sp1 is a Co-Activator with Ets-1, and Net is an Important Repressor of the Transcription of CTP:phosphocholine Cytidylyltransferase Alpha. J. Biol. Chem. 280, 40857-40866.

Alam, M., Gilham, D., Vance, D.E. and Lehner, R. (2006) Mutation of F417 but not of L418 or L420 in the Putative Neutral Lipid Binding Domain Results in Decreased Activity of Human Triacylglycerol Hydrolase. J. Lipid. Res. 47, 375-383.

Karten, B., Campenot, R.B., Vance, D.E. and Vance, J.E. (2006) Niemann-Pick C1 Protein in Recycling Endosomes of Pre-synaptic Nerve Terminals. J. Lipid. Res. 47, 504-514.

Sher, R.B., Aoyoma, C., Huebsch, K.A., Shaonin Ji, S., Kerner, J., Yang, Y., Frankel, W.N., Hoppel, C.L., Wood, P.A. Vance, D.E. and Cox, G.A. (2006) A Rostrocaudal Muscular Dystrophy Caused by a Defect in Choline Kinase Beta, the First Enzyme in Phosphatidylcholine Biosynthesis. J. Biol. Chem. 281: 4938-4948.

Stead, L.M., Brosnan, J.T., Brosnan, M.E., Vance, D.E. and Jacobs, R.L. (2006) Is it Time to Re-evaluate Methyl Balance in Humans? Amer. J. Clin. Nutr. 83, 5-10.

Karten, B., Campenot, R.B., Vance, D.E. and Vance, J.E. (2006) Expression of ABCG1, But Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia. J. Biol. Chem. 281: 4049-4057.

Banchio, C., Lingrell, S. and Vance, D.E. (2006) Role of Histone Deacetylase in the Expression of CTP:Phosphocholine Cytidylyltransferase a. J. Biol. Chem. 281: 10010-10015.

Li, Z., Agellon, L.B., Allen, T.M., Umeda, M., Jewell, L., Mason, A. and Vance, D.E. (2006) The Ratio of Phosphatidylcholine to Phosphatidylethanolamine Influences Membrane Integrity and Steatohepatitis. Cell Metabolism, 3: 321-331.

Huei-Ju Pan, Steve Watkins, Yimin Lin, Eugene Chen, Dennis E. Vance, Chul-Ho Lee and Edward H. Leiter (2006) Adverse Hepatic and Cardiac Responses to Rosiglitazone in a New Mouse Model of Type 2 Diabetes: Relation to Dysregulated Phosphatidylcholine Metabolism. J. Vasc. Pharma. 45, 65-71.

Hartz, C.S., Nieman, K.M., Jacobs, R.L., Vance, D.E. and Schalinske, K.L. (2006) Hepatic Phosphatidylethanolamine N- Methyltransferase Expression is Increased in Diabetic Rats. J. Nutrition 136, 3005-3009.

Jacobs, R.L., Lingrell, S., Dyck, J.R.B. and Vance, D.E. (2007) Inhibition of Hepatic Phosphatidylcholine Synthesis by 5-Aminoimidazole-4-carboxamide-1-b-4-ribofuranoside Is Independent of AMP-activated Protein Kinase Activation. J. Biol. Chem. 282, 4516-4523.

Mudd, S.H., Brosnan, J.T., Brosnan, M.E., Jacobs, R.L., Stabler, S.P., Allen, R.H. Vance, D.E. and Wagner, Conrad (2007) Methyl Balance and Transmethylation Fluxes in Humans. Am. J. Clin. Nutr. 85: 19-25.

LI, Z. and Vance, D.E. (2007) Choline Cannot Be Replaced by Propanolamine in Mice. BBA Mol. Cell Biol. Lipids 1771, 486-490.

Hayashi, H., Campenot, R.B., Vance, D.E. and Vance, J.E. (2007) Apolipoprotein E-containing Lipoproteins Protect Neurons from Apoptosis via a Signaling Pathway Involving Low Density Lipoprotein Receptor-Related Protein-1. J. Neurosci. 27, 1933-1941.

Li, Z., Agellon, L.B. and Vance, D.E. (2007) Choline Redistribution during Adaptation to Choline Deprivation. J. Biol. Chem. 282, 10283-10289.

Banchio, C., Lingrell, S. and Vance, D.E. (2007) Sp-1 Binds Promoter Elements that Are Regulated by Rb and Regulate CTP:phosphocholine Cytidylyltransferase-a Transcription. J. Biol. Chem. 282, 14827-14835.

Li, Z., Agellon, L.B. and Vance, D.E. (2007) A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis. BBA Mol. Cell Biol. Lipids, 1771, 893-900.

Burnett. J.R., Zhong, S., Jiang, Z.G., Hooper, A.J., Fisher, E.A., McLeod, R.S., Zhao, Y., Barrett, P.H.R., Hegele, R.A., van Bockxmeer, F.M., Zhang, H, Vance, D.E., McKnight, C.J. and Yao, Z. (2007) Missense Mutations in Apo B Within the ba1 Domain of Human Apo B-100 Result in Impaired Secretion of Apo B and Apo B-containing Lipoproteins in Familial Hypobetalipoproteiniemia. J. Biol. Chem. 282, 24270-24283.

Verkade, H.J., Havinga, R., Shields, D.J., Wolters, H., Bloks, V.W., Kuipers, F., Vance, D.E. and Agellon, L.B. (2007) The Phosphatidylethanolamine N-Methyltransferase Pathway Is Quantitatively not Essential for Biliary Phosphatidylcholine Secretion. J. Lipid Res., 48, 2058-2064.

Aoyama, C., Ishidate, K., Sugimoto, H. and Vance, D.E. (2007) Induction of Choline Kinase alpha by Carbon Tetrachloride (CCl₄) Occurs via Increased Binding of c-Jun to an AP-1 Element. BBA Mol. Cell Biol. Lipids, 1771, 1148-1155 .

Koonen, D.P.Y., Jacobs, R.L., Febbraio, M., Young, M.E., Soltys, C.M., Ong,^. H., Vance, D.E. and Dyck, J.R.B. (2007) Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated with Diet-Induced Obesity. Diabetes, 56, 2863-2871.

Wei, E., Alam, M., Sun, F., Agellon, L.B., Vance, D.E. and Lehner, R. (2007) Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice. J. Lipid Res. 48, 2597-2606.

Carter, J.M., Demizieux, L., Campenot, R.B., Vance, D.E. and Vance, J.E. (2008) Phosphatidylcholine Biosynthesis via CTP:Phosphocholine Cytidylyltransferase beta2 Facilitates Neurite Outgrowth and Branching. J. Biol. Chem. 283, 202-212.

Wu, G., Aoyama, C., Young, S.G. and Vance, D. E. (2008) Early Embryonic Lethality Caused by Disruption of the Gene for Choline Kinase Alpha, the First Enzyme in Phosphatidylcholine Biosynthesis. J. Biol. Chem. 283, 1456-1462.

Jacobs, R.L., Lingrell, S., Zhao, Y, Francis, G.A. and Vance, D.E. (2008) Hepatic CTP:phosphocholine Cytidylyltransferase-alpha is a Critical Predictor of Plasma HDL and VLDL. J. Biol. Chem. 283, 2147- 2155.

Minahk. C., Kim, K.-W., Nelson, R., Trigatti, B., Lehner. R. and Vance, D.E. (2008) Conversion of Low Density Lipoprotein-Associated Phosphatidylcholine to Triacylglycerol by Primary Hepatocytes. J. Biol. Chem., 283, 6449-6458.

Ji, C., Shinohara, M., Vance, D.E., Than, T.A., Ookhtens, M., Chan, C., Kaplowitz, N. (2008) Efect of Transgenic Extrahepatic Expression of Betaine-Homocysteine Methyltransferase on Alcohol or Homocysteine-Induced Fatty Liver. Alcohol. Clin. Exp. Res. 32, 1049-1058.

Robichaud, J.C., Francis, G.A. and Vance, D.E. (2008) A Role for Hepatic Scavenger Receptor Class B, Type I in Decreasing High-Density Lipoprotein Levels in Mice that Lack Phosphatidylethanolamine N-Methyltransferase. J. Biol. Chem. 283, 35496-35506.

Robichaud, J.C., van der Veen, J.N., Yao, Z., Trigatti, B. and Vance, D.E. (2009) Hepatic Uptake and Metabolism of Phosphatidylcholine Associated with High Density Lipoproteins. Biochim. Biophys. Acta 1790, 538-551.

Wu, Gengshu, Sher, R.B., Cox, G.A. and Vance, D.E. (2009) Understanding the Muscular Dystrophy Caused by Deletion of Choline Kinase Beta in Mice. Biochim. Biophys. Acta 1791, 347-356.

Okamura, K., Yamashita, S., Ando, H., Horibata, Y. Aoyama, C., Takagishi, K., Izumi, T., Vance, D.E. and Sugimto, H. (2009) Identification of Nuclear Localization and Nuclear Export Signals in Ets2 and the Transcriptional Regulation of Ets2 and CTP:Phosphocholine Cytidylyltransferase a in Tetradecanoyl-13-Acetate or Macrophage-Colony Stimulating Factor Stimulated RAW264 Cells. Biochim. Biophys. Acta 1791, 173-182.

Zhao, Y., Su, B., Jacobs, R.L., Kennedy, B., Francis, G.A., Waddington, E., Brosnan, J.T., Vance, J.E. and Vance, D.E. (2009) Lack of Phosphatidylethanolamine N-Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice. Arteriosclerosis Thromb. Vasc. Biol. 29, 1349-1355.

Hayashi, H., Campenot, R.B., Vance, D.E. and Vance, J.E. (2009) Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase C gamma1 and inhibition of calcineurin. J. Biol. Chem. 284, 29605-29613.

Wu, Gengshu, Sher, R.B., Cox, G.A. and Vance, D.E. (2010). Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse. Biochim. Biophys. Acta In Press.

Vance, D.E. and Spener, F. (2004) Henk van den Bosch: Chemist and Biochemist, Biochim. Biophys. Acta, 1636, 77-81.

Vance, J.E. and Vance, D.E. (2004) Phospholipid Biosynthesis in Mammalian Cells, Biochem. Cell Biol. 82, 113-128.

Dolinsky, V.W., Gilham, D., Alam, M., Vance, D.E. and Lehner, R. (2004) Triacylglycerol Hydrolase: Role in Intracellular Lipid Metabolism, Cellular Mol. Life Sci. 61, 1633-1651.

Hayashi, H., Karten, B., Vance, D.E. , Campenot, R.B., Maue, R.A. and Vance, J.E. (2004) Methods for the Study of Lipid Metabolism in Neurons. Anal. Biochem. 331, 1-16.

Vance, D.E. (2005) Phospholipids in Encyclopedia of Molecular Cell Biology and Molecular Medicine Vol. 10 (2^nd Edition) (Ed. R.A. Meyers) Wiley-VCH, Weinheim, Germany. 277-306.

Vance, J.E. and Vance, D.E. (2005) Metabolic Insights into Phospholipid Function Using Gene-Targeted Mice J. Biol. Chem. 280, 10877-10880.

Karten, B., Hayashi, H., Campenot, R.B., Vance, D.E. and Vance. J.E. (2005) Neuronal Models for Studying Lipid Metabolism and Transport Methods 36, 117-128.

Vance, D.E. (2006) Canadian Biochemistry, Molecular Biology and Cell Biology on the Flat Earth. CSBMCB Bulletin 2005, 58-61.

Vance, D.E. (2006) Fundamental Research is the Basis for Understanding and Treatment of Many Human Diseases. FEBS Lett. 580, 5430-5435.

Vance. D.E. (2007) BBA in the Year 2007. Biochim. Biophys. Acta 1775, 3-4.

Vance, D.E., Li, Z. and Jacobs, R.L. (2007) Hepatic Phosphatidylethanolamine N-Methyltransferase-Unexpected Roles in Animal Biochemistry and Physiology. J. Biol. Chem. 282, 33237-33241.

Vance, D.E. and Vance, J.E. (2008) Phospholipid Biosynthesis in Eukaryotes In Biochemistry of Lipids, Lipoproteins and Membranes, 5^th Edition. (Eds. D.E. Vance and J.E. Vance), Elsevier Science B.V. 213-244.

Sugimoto, H., Banchio, C. and Vance, D.E. (2008) Transcripitonal Regulation of Phosphatidylcholine Biosynthesis. Progress Lipid Res. 47, 204-220.

Li, Z. and Vance, D.E. (2008) Phosphatidylcholine and Choline Homeostasis. J. Lipid Res. 49, 1187-1194.

Vance, D.E. (2008) Role of Phosphatidylcholine Biosynthesis in Regulation of Lipoprotein Homeostasis. Curr. Opin. Lipidology. 19, 229-234.

Vance, D.E. and Vance, J.E. (2009) Physiological Consequences of disruption of mammalian phospholipid biosynthetic genes. J. Lipid Res. S132-S137.

Edition of Books and Special Issues of Journals:

Vance, D.E. and Spener, F. (2004) Special Issue Dedicated to Henk van den Bosch, Biochim. Biophys. Acta 1636, 77-231

Vance, D.E. (Editor) (2005) Recent Methods in Molecular and Cell Biology of Lipids, Methods, 36, 97-22

Vance, D.E. and Vance, J.E. (2008) Editors for Biochemistry of Lipids, Lipoproteins and Membranes (5^th edition) Elsevier Science Publishers, San Diego, 1-631